Medical titanium alloys are not only non-toxic, lightweight, and anti-corrosion, but also have excellent biocompatibility and natural ability to integrate with human bone, it can be used as implants implanted into the human body, and so on, which are ideal medical metallic materials.
Marvel Universe's X-Men series films, Wolverine's titanium alloy human bones show their power and are indestructible. If we change the medical titanium alloy into the body in the real world or replace our bones with Ti bones, will we become stronger?
On November 25, 2021, Tianjin University, Hebei University of Technology, Hubei University, and other research institutions published a research paper entitled "Self-activating anti-infection implant" in nature communication, The results showed that Ti6Al4V (ti6) titanium alloy implant modified by HA / MoS2 coating showed a high antibacterial effect on Staphylococcus aureus and Escherichia coli, it could accelerate bone regeneration by promoting the osteogenic differentiation of mesenchymal stem cells.
In clinical bone surgery, it is difficult to endow the implant with the good osteogenic ability and antibacterial activity at the same time. Bacterial infection and bone tissue integration with host tissue delayed the recovery time and increased the incidence rate. The key to implant success lies in the rapid osteogenic differentiation of osteoblasts on the implant and the prevention of bacterial infection at the same time.
Hydroxyapatite (HA) has good bone conductivity, it has been widely used in the bone integration of dental and orthopedic implants. In addition to good biocompatibility, molybdenum sulfide (MoS2) has unique physical and photoelectric properties, which makes it have excellent bactericidal ability against gram-positive and Gram-negative bacteria.
In this study, the researchers prepared the above two materials into HA / MoS2 coating modified Ti6Al4V (ti6) implants by laser cladding and chemical vapor deposition (CVD). HA, / MoS2 coating uses the energy generated by the metabolic process of Staphylococcus aureus and Escherichia coli to trigger the antibacterial activity of HA / mos2-ti6 without additional energy. it is a self-activated anti-infection process. At the same time, it can improve the survival rate of bone marrow mesenchymal stem cells and promote the osteogenic differentiation of bone marrow mesenchymal stem cells by up-regulating the level of Ca2 +.
Note: HA / MoS2 coating can prevent bacterial infection and promote bone tissue regeneration
